6-AMINOPYRAZOLOPYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF

A 6-aminopyrazolopyrimidine compound, or a pharmaceutically acceptable salt thereof, having NLRP3 inflammasome inhibitory activity, a pharmaceutical composition comprising the same, and their medical use, etc., are provided.A compound of Formula [IA]:or a pharmaceutically acceptable salt thereof,wherein a partial structure:is a structure of the following formula:etc.wherein R4 is hydrogen or C1-4 alkyl, in which the alkyl may be optionally substituted with hydroxy or cyano,Ring group CyA is a group of the following formula:etc.wherein R6 and R7 are, each independently, hydrogen, hydroxy, cyano, C1-6 alkyl, etc., R8 and R9 are, each independently, hydrogen, C1-4 alkyl, or C1-4 haloalkyl, R10 is hydrogen, cyano, C1-6 alkyl, etc.),R1 is hydrogen or C1-4 alkyl,R2A and R3A are, each independently, hydrogen, C1-6 alkyl etc., alternatively, R2A and R3A may combine together with the nitrogen atom to which they attach and the -NR2AR3A group may form a 4- to 7-membered optionally-substituted heterocycloalkyl, etc.