METHOD FOR REGULATING THE BIOFILM FORMATION ABILITY OF BACILLUS SUBTILIS

The present invention discloses a method for regulating the biofilm formation ability of Bacillus subtilis. This method alters the self-agglutination ability and membrane characteristics of Bacillus subtilis by overexpression of expression level of the men series genes, thereby altering the biofilm formation ability of Bacillus subtilis. As a model microorganism for studying biofilm, it can regulate the biofilm formation ability of Bacillus subtilis, which provides a new idea for regulating the formation of Gram-positive bacteria biofilm and weakening the antibiotic tolerance of pathogenic microorganisms. It has great practical significance and broad application prospects in the fields of biological prevention and health care.