PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME

PEPTIDE FOR THE TREATMENT OF CYTOKINE STORM SYNDROME

Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cy...

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Hauptverfasser: NODARSE CUNI, Hugo, GUILLEN NIETO, Gerardo Enrique, VENEGAS RODRIGUEZ, Rafael, GARAY PEREZ, Hilda Elisa, MARTÍNEZ DONATO, Gillian, DOMÍNGUEZ HORTA, María del Carmen, HERNÁNDEZ CEDEÑO, Mabel, ORTEGA GONZÁLEZ, Lilia María, LOPEZ ABAD, Cruz Matilde, UBIETA GÓMEZ, Raimundo
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Pharmaceutical composition comprising the APL-type peptide identified as SEQ ID NO: 1, as an inhibitor of a state of hyperinflammation characterized by an increase in cytokines or interleukins and inflammatory molecules, which increase their concentration until reaching the state defined as "cytokine storm". The sucrose concentrations in said composition increase the biological activity of the peptide, facilitating its intravenous application. Said peptide in a pharmaceutical composition is useful for the manufacture of a drug to treat diseases related to hyperinflammation, such as Covid-19, dengue, macrophage activation syndrome, respiratory sepsis and chimeric antigen receptor T-Cell therapies, and acute respiratory distress syndrome. It also discloses a method for the treatment of said diseases, administering a therapeutically effective amount of the composition.