SUBSTITUTED TRICYCLIC COMPOUNDS

SUBSTITUTED TRICYCLIC COMPOUNDS

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferativ...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PHUKAN, Samiron, NAIR, Prathap Sreedharan, PALLE, Venkata P, WAGH, Pradip Balu, KAMBOJ, Rajender Kumar, DUBE, Dagadu, TAMBE, Vikas Sitaram, PATIL, Pradeep Rangrao, SETHI, Sachin, SINDKHEDKAR, Milind Dattatraya, BALGUDE, Sudhakar Maruti, SHUKLA, Manojkumar Ramprasad, KAKADE, Ganesh, KHEDKAR, Nilesh Raghunath
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.