COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASE

COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASE

Disclosed are compositions and methods for treating a liver disease in a subject by increasing transport or retention of HNF4α, a transcriptional factor, into a nucleus of a hepatocyte in the subject. In some embodiments, the method comprises upregulating expression or function of one or more transc...

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Hauptverfasser: SARAH HAINER, ALEJANDRO SOTO GUTIERREZ, AARON BELL, JORGE GUZMAN LEPE, EDGAR NAOE TAFALENG, NICOLAS FRAUNHOFFER NAVARRO, GEORGE K MICHALOPOULOS, IRA FOX, ALINA OSTROWSKA, KAZUKI TAKEISHI
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creator SARAH HAINER
ALEJANDRO SOTO GUTIERREZ
AARON BELL
JORGE GUZMAN LEPE
EDGAR NAOE TAFALENG
NICOLAS FRAUNHOFFER NAVARRO
GEORGE K MICHALOPOULOS
IRA FOX
ALINA OSTROWSKA
KAZUKI TAKEISHI
description Disclosed are compositions and methods for treating a liver disease in a subject by increasing transport or retention of HNF4α, a transcriptional factor, into a nucleus of a hepatocyte in the subject. In some embodiments, the method comprises upregulating expression or function of one or more transcription factors selected from the group consisting of PROX1, NR5A2, NROB2, MTF1, SREBP1, EP300, and POM121C, and functional fragments thereof, and/or downregulating expression or function of one or more transcription factors DNAJB 1/F1SP40, ATF6, ATF4, and PERK, and functional fragments thereof.
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title COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASE
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