COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASE

COMPOSITIONS AND METHODS FOR TREATING LIVER DISEASE

Disclosed are compositions and methods for treating a liver disease in a subject by increasing transport or retention of HNF4α, a transcriptional factor, into a nucleus of a hepatocyte in the subject. In some embodiments, the method comprises upregulating expression or function of one or more transc...

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Hauptverfasser: SARAH HAINER, ALEJANDRO SOTO GUTIERREZ, AARON BELL, JORGE GUZMAN LEPE, EDGAR NAOE TAFALENG, NICOLAS FRAUNHOFFER NAVARRO, GEORGE K MICHALOPOULOS, IRA FOX, ALINA OSTROWSKA, KAZUKI TAKEISHI
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are compositions and methods for treating a liver disease in a subject by increasing transport or retention of HNF4α, a transcriptional factor, into a nucleus of a hepatocyte in the subject. In some embodiments, the method comprises upregulating expression or function of one or more transcription factors selected from the group consisting of PROX1, NR5A2, NROB2, MTF1, SREBP1, EP300, and POM121C, and functional fragments thereof, and/or downregulating expression or function of one or more transcription factors DNAJB 1/F1SP40, ATF6, ATF4, and PERK, and functional fragments thereof.