RI-LABELED HUMANIZED ANTIBODY

The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the aforementioned radionuclide is a metal nuclide emitting α particle or positron, and the aforementioned antibody is a humanized antibody specifi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TAKAYUKI MURAKAMI, NOBUYA KOBASHI, NORIHITO NAKATA, YASUSHI OCHIAI, YOSHINARI SHOYAMA, MITSUHIRO MATONO
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the aforementioned radionuclide is a metal nuclide emitting α particle or positron, and the aforementioned antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.