HUMAN RECOMBINANT HYPOSIALYLATED ERYTHROPOIETIN, METHODS OF PURIFICATION AND THERAPEUTIC USES THEREOF

HUMAN RECOMBINANT HYPOSIALYLATED ERYTHROPOIETIN, METHODS OF PURIFICATION AND THERAPEUTIC USES THEREOF

The present invention relates to the fields of biotechnology and medicine and describes a pharmaceutical composition of recombinant human erythropoietin having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-antennary structures with mono and bi-sialylated sialic acid resid...

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Hauptverfasser: AMARO GONZÁLEZ, Daniel Enrique, DÍAZ GOIRE, Dayli, SARMIENTO CONDE, Yanara, GIMÉNEZ LÓPEZ, Estela, GARCÍA ARTALEJO, Judey Aymed, RODRÍGUEZ OBAYA, Teresita de Jesus, SOSA TESTÉ, Iliana Maria, HERNÁNDEZ DE LA ROSA, Lourdes
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to the fields of biotechnology and medicine and describes a pharmaceutical composition of recombinant human erythropoietin having a microheterogeneity of fucosylated N-glycans formed by bi, tri and tetra-antennary structures with mono and bi-sialylated sialic acid residues that represent 40-60% of the total glycans, trisialylated ones that represent 40-43% of the total glycans, and tetrasialylated ones that represent 10-13% of the total glycans. This glycosylation pattern confers properties to said composition that allow for its use in disorders of the nervous system. The invention also relates to the method of obtaining said pharmaceutical composition.