METHOD FOR OBTAINING LOW-MOLECULAR-WEIGHT HEPARINS BY MEANS OF TANGENTIAL FLOW FILTRATION

The invention relates to a method for obtaining low-molecular-weight heparins (LMWH) with a molecular weight distribution of 3.0-5.0 kDa, which comprises at least one step of concentrating by means of tangential flow filtration (TFF). The process is particularly useful for the preparation of bemiparin and enoxaparin without the use of fractional precipitation or the use of alcoholic solutions. In particular, the preparation of LMWH is achieved by means of the depolymerisation of heparin and the filtration (TFF diafiltration and/or ultrafiltration) of the depolymerised heparin without using fractional precipitation and without alcoholic solution.