BCMA CHIMERIC ANTIGEN RECEPTOR BASED ON SINGLE DOMAIN ANTIBODY AND USE THEREOF

BCMA CHIMERIC ANTIGEN RECEPTOR BASED ON SINGLE DOMAIN ANTIBODY AND USE THEREOF

A chimeric antigen receptor (CAR) and the use thereof, the CAR comprising: a BCMA binding domain, a transmembrane domain, one or more co-stimulatory domains, and an intracellular signaling domain, wherein the BCMA binding domain comprises heavy chain complementarity determining regions HCDR1-3, and...

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Bibliographische Detailangaben
Hauptverfasser: SU, Hongchang, BAO, Chaolemeng, CAI, Qinghua, LI, Hongjian, DING, Yijin, SONG, Zongpei, ZHANG, Jishuai, CAI, Zhibo
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
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Beschreibung
Zusammenfassung:A chimeric antigen receptor (CAR) and the use thereof, the CAR comprising: a BCMA binding domain, a transmembrane domain, one or more co-stimulatory domains, and an intracellular signaling domain, wherein the BCMA binding domain comprises heavy chain complementarity determining regions HCDR1-3, and the amino acid sequences of the HCDR1-3 are successively as shown in SEQ ID NO: 1-3.