N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS

N-SUBSTITUTED-DIOXOCYCLOBUTENYLAMINO-3-HYDROXY-PICOLINAMIDES USEFUL AS CCR6 INHIBITORS

The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B)or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of...

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Hauptverfasser: ROBINSON, JR., RALPH PELTON, LOMBARDO, Vincent, Michael, NUHANT, Philippe, Marcel, SCHNUTE, Mark Edward, SCHMITT, Daniel, Copley, MOUSSEAU, James, John, FLICK, Andrew, Christopher, KUNG, Daniel Wei-Shung, THORARENSEN, Atli, UNWALLA, Rayomand, Jal, GERSTENBERGER, Brian, Stephen, WU, Huixian, TRUJILLO, John Isidro
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamide compounds of Formulae (IA and 1B)or a pharmaceutically acceptable salt or hydrate thereof, that inhibit CC chemokine receptor 6 (CCR6), pharmaceutical compositions containing these compounds, and the use of these compounds for treating or preventing diseases, conditions, or disorders ameliorated by inhibition of CCR6.