FUSION CONSTRUCTS AND METHODS OF USING THEREOF

FUSION CONSTRUCTS AND METHODS OF USING THEREOF

Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF- trap. Provided herein is a composition comprising a fusion protein or a fragment thereof or a variant thereof comprising an anti-PD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHANGHUNG CHEN, SIMON METENOU, RUTUL R SHAH, HELEN SABZEVARI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF- trap. Provided herein is a composition comprising a fusion protein or a fragment thereof or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a ADA2 polypeptide. Also provided herein are methods of using the composition in treating cancer.