A THREE-PROTEIN PROTEOMIC BIOMARKER FOR PROSPECTIVE DETERMINATION OF RISK FOR DEVELOPMENT OF ACTIVE TUBERCULOSIS

A THREE-PROTEIN PROTEOMIC BIOMARKER FOR PROSPECTIVE DETERMINATION OF RISK FOR DEVELOPMENT OF ACTIVE TUBERCULOSIS

The invention relates to a method and kit for determining a likelihood of a human subject with asymptomatic tuberculosis (TB) infection or suspected TB infection progressing to active tuberculosis disease, the method comprising detecting a presence or level of a first and a second pair of protein bi...

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Hauptverfasser: ZAK, Daniel Edward, SCRIBA, Thomas Jens, THOMPSON, Ethan Greene, PENN-NICHOLSON, Adam Garth
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to a method and kit for determining a likelihood of a human subject with asymptomatic tuberculosis (TB) infection or suspected TB infection progressing to active tuberculosis disease, the method comprising detecting a presence or level of a first and a second pair of protein biomarkers selected from Complement Component 9 (C9) and Complement C1q Tumor Necrosis Factor-Related Protein 3 (C1qTNF3); and C9 and Creatine Kinase M- and B-type (CKMB) in a sample from the subject.