NOVEL METHOD FOR SYNTHESIZING AMANITINS

The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4′, 5′ or 7′ of the central tryptophan moiety, no...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Werner SIMON (German Citizen), Thorsten HECHLER (German Citizen), Michael KULKE (German Citizen), Christoph MÜLLER (German Citizen), Christian LUTZ (German Citizen), Susanne WERNER-SIMON (German Citizen)
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4′, 5′ or 7′ of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.