ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE)

ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE)

A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest Also provided are a composition, such as a pharmaceutical formulat...

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Bibliographische Detailangaben
Hauptverfasser: BROMLEY (né BROWN), Alice Claire Noel, FREEDMAN, Joshua, David, FISHER, Kerry, David, CHAMPION, Brian Robert, SEYMOUR, Leonard, William
Format: Patent
Sprache:eng
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Zusammenfassung:A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell engager comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.