POLYMORPHIC FORMS OF (9-[(R)-2-[[(S)-[[(S)-1- (ISOPROPOXYCARBONYL)ETHYL]AMINO]PHENOXY PHOSPHINYL]METHOXY]PROPYL] ADENINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

POLYMORPHIC FORMS OF (9-[(R)-2-[[(S)-[[(S)-1- (ISOPROPOXYCARBONYL)ETHYL]AMINO]PHENOXY PHOSPHINYL]METHOXY]PROPYL] ADENINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The present invention discloses novel crystalline polymorphic forms of (9-[(R)-2-[[(S)-[[(S)-1-(isopropoxy carbonyl) ethyl] amino] phenoxyphosphinyl] methoxy]propyl] adenine hemifumarate and 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl] amino]phenoxy phosphinyl]methoxy]propyl] adenine monofumara...

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Hauptverfasser: MALHOTRA, Geena, CHENNURU, Ramanaiah, PATHI, Srinivas Laxminarayan, RAO, Dharmaraj Ramachandra, PHULL, Manjinder Singh
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention discloses novel crystalline polymorphic forms of (9-[(R)-2-[[(S)-[[(S)-1-(isopropoxy carbonyl) ethyl] amino] phenoxyphosphinyl] methoxy]propyl] adenine hemifumarate and 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl] amino]phenoxy phosphinyl]methoxy]propyl] adenine monofumarate, methods of preparation, pharmaceutical compositions and methods of therapeutic treatment involving polymorphic forms thereof.