CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS

CYCLOPROPYL-AMIDE COMPOUNDS AS DUAL LSD1/HDAC INHIBITORS

The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDA...

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Hauptverfasser: PURUSHOTTAM DEWANG, SREEKALA NAIR, KANNAN MURUGAN, SRIRAM RAJAGOPAL, SRIDHARAN RAJAGOPAL, CHANDRIKA MULAKALA, MOHD ZAINUDDIN, MAHANANDEESHA S HALLUR, DHANALAKSHMI SIVANANDHAN, PRAVIN IYER, SUBRAMANYAM JANARDHAN TANTRY, CHANDRU GAJENDRAN, DURGA PRASANNA KUMAR C.H
Format: Patent
Sprache:eng
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Zusammenfassung:The present disclosure describes novel compounds of the general Formula (I), their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds can inhibit both LSD and HDAC and are useful as therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, parkinson's disease and the like.