DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE

DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE

Derivatives of Amernita toxins of Formula (I), wherein, formula (a) R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, X, L, m, n and Q are defined herein. The preparation of the derivatives. The therapeutic use of the derivatives in the targeted treatment of cancers, autoimmune disorders, and infec...

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Hauptverfasser: ZHAO, Robert Yongxin, LI, Wenjun, GAI, Shun, HUANG, Yuanyuan, GUO, Zixiang, JIA, Junxiang, YANG, Qingliang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LIN, Chen, ZUO, Xiaotao, YANG, Chengyu, CAO, Minjun, TONG, Qianqian, XIE, Hongsheng, ZHAO, Linyao, YE, Hangbo
Format: Patent
Sprache:eng
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Zusammenfassung:Derivatives of Amernita toxins of Formula (I), wherein, formula (a) R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, X, L, m, n and Q are defined herein. The preparation of the derivatives. The therapeutic use of the derivatives in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.