PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS ¿ CRYSTALLINE TOLUENE SOLVATE OF (S)¿AFOXOLANER

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED ISOXAZOLINE COMPOUNDS ¿ CRYSTALLINE TOLUENE SOLVATE OF (S)¿AFOXOLANER

This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine- based chiral phase transfer catalysts. The invention also relates to novel quinine-based phase transfer catalysts and to a crystalline toluene solvate form of (S)-a...

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Bibliographische Detailangaben
Hauptverfasser: MENG, Charles, Q, GORTER DE VRIES, Roelof, Johannes, GAY DE SAINT MICHEL, Myriam, BAILLON, Bruno, KOZLOVIC, Stephane, LAFONT Sylvaine, LONG, Alan, LE HIR DE FALLOIS, Loic, Patrick, YANG, Chunhua
Format: Patent
Sprache:eng
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Zusammenfassung:This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine- based chiral phase transfer catalysts. The invention also relates to novel quinine-based phase transfer catalysts and to a crystalline toluene solvate form of (S)-afoxolaner.