NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compound...

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Hauptverfasser: LAXMIKANT ATMARAM GHARAT, SANDEEP YADUNATH SHELKE, ABRAHAM THOMAS, NEELIMA KHAIRATKAR-JOSHI, SANJIB DAS, RAJENDRA LAXMAN HARDE, SHAILESH RAMESH PARDESHI, MALINI BAJPAI, DAISY MANISH SHAH
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creator LAXMIKANT ATMARAM GHARAT
SANDEEP YADUNATH SHELKE
ABRAHAM THOMAS
NEELIMA KHAIRATKAR-JOSHI
SANJIB DAS
RAJENDRA LAXMAN HARDE
SHAILESH RAMESH PARDESHI
MALINI BAJPAI
DAISY MANISH SHAH
description The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.</abstract><oa>free_for_read</oa></addata></record>
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