NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compound...

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Hauptverfasser: LAXMIKANT ATMARAM GHARAT, SANDEEP YADUNATH SHELKE, ABRAHAM THOMAS, NEELIMA KHAIRATKAR-JOSHI, SANJIB DAS, RAJENDRA LAXMAN HARDE, SHAILESH RAMESH PARDESHI, MALINI BAJPAI, DAISY MANISH SHAH
Format: Patent
Sprache:eng
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Zusammenfassung:The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.