ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF

ANTIBODIES SPECIFIC FOR HYPERPHOSPHORYLATED TAU AND METHODS OF USE THEREOF

The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer'...

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Hauptverfasser: JUSTUS CLAUS ALFRED DÄCHSEL, AYODEJI ABDUR-RASHEED ASUNI, NINA ROSENQVIST, JAN TORLEIF PEDERSEN, LARS ØSTERGAARD PEDERSEN
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.