MODIFIED DNASE AND USES THEREOF

MODIFIED DNASE AND USES THEREOF

Modified DNase l protein in which one or more amino acids of a DNase l protein are modified non-cellularly, are provided. The modified DNase l protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase l pro...

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Bibliographische Detailangaben
Hauptverfasser: SHAALTIEL, Yoseph, RUDERFER, Ilya, UGORTSEV, Yulia, NETA, Hagit, GELLEY, Sivan, CHEN ZELTSBURG, Lilach, FUX, Liat, LAVEE LAVIAD, Elad, SHULMAN, Avidor
Format: Patent
Sprache:eng
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Zusammenfassung:Modified DNase l protein in which one or more amino acids of a DNase l protein are modified non-cellularly, are provided. The modified DNase l protein exhibits a DNA hydrolytic activity in the presence of actin and an improved DNA hydrolytic activity compared to a homologous non-modified DNase l protein. Processes of preparing the modified DNase l protein and uses thereof in, for example, reducing a DNA content in sputum and/or in treating a disease or condition associated with excess extracellular DNA in a fluid, secretion or tissue of a subject, are also provided.