IMPROVED FEEDING STRATEGIES AND PURIFICATION PROCESSES FOR MONOCLONAL ANTIBODY PRODUCTION

IMPROVED FEEDING STRATEGIES AND PURIFICATION PROCESSES FOR MONOCLONAL ANTIBODY PRODUCTION

This invention provides an improved process for manufacturing a Rabies monoclonal antibody (HuMab 17C7) that results in low osmolality, minimum secondary metabolites like ammonia and lactate, enhanced cell growth and productivity, minimum aggregation or degradation of monoclonal antibody during puri...

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Bibliographische Detailangaben
Hauptverfasser: GUPTA, Pardeep, REDDY, Peddi Reddy Srinivas, CHAHAR, Singh Digamber, MHALASAKANT, Dhere Rajeev, SHANKAR, Pisal Sambhaji
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention provides an improved process for manufacturing a Rabies monoclonal antibody (HuMab 17C7) that results in low osmolality, minimum secondary metabolites like ammonia and lactate, enhanced cell growth and productivity, minimum aggregation or degradation of monoclonal antibody during purification, thereby improving potency of monoclonal antibody (HuMab 17C7) as compared to human rabies immunoglobulin (hRIG).