NOVEL MANGANESE COMPRISING NANOSTRUCTURES

Disclosed herein are nanostructures comprising manganese ions incorporated in a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as -R 3 R 4 C(P=O(OR 2 )(OR2))2, wherein R 1 and R 2 are...

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Bibliographische Detailangaben
Hauptverfasser:	EK,FREDEDRIK, PETORAL JR,RODRIGO M, AXELSSON,OSKAR, LAURITZSON,PETTER
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT THEREOF MEDICAL OR VETERINARY SCIENCE NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TRANSPORTING
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Beschreibung
Zusammenfassung:	Disclosed herein are nanostructures comprising manganese ions incorporated in a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as -R 3 R 4 C(P=O(OR 2 )(OR2))2, wherein R 1 and R 2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R 3 and R 4 is a group connected to the polymeric framework with the proviso that when only one of R 3 and R 4 is such a connected group, the other of R 3 and R 4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR 5 and R 5 , wherein R 5 is a lower alkyl. Disclosed are also methods for producing such nanostructures, compositions comprising such nanostructures and use of such nanostructures, i.a. as MRI contrasting agents.