MONOCLONAL ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF

MONOCLONAL ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF

The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BARLOW EVE H, BARDWELL PHILLIP D, HSIEH CHUNG-MING, LEDDY MARY R, SCHMIDIT MARTIN, MULLER BERNHARD K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.