HIV INTEGRASE INHIBITORS

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of A...

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Hauptverfasser: SU DAI-SHI, FISHER THORSTEN E, WAI JOHN S, CHOI ERIC J, WILLIAMS PETER D, DUBOST DAVID C, EMBREY MARK W, ISAACS RICHARD C A, THOMPSON WAYNE J, PEI TAO, BALL RICHARD G, VENKATRAMAN SHANKAR, TRICE SARAH L
Format: Patent
Sprache:eng
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Zusammenfassung:Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein X1, X2, Y, R1A, R1B, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Processes for making compounds of Formula I and intermediates thereof are also described.