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Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for...

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Hauptverfasser:	KACHHADIA VIRENDRA, JANARTHANAM VENKATESAN, VISHWAKARMA LOLAKNATH SANTOSH, GADDE SATHYANARAYANA, RAMACHANDRAN UMA, REDDY GADDAM OM, NARAYANAN SHRIDHAR, NARAYANAM MARUTHIKUMAR, BALASUBRAMANIAN GOPALAN, NARASIMHAN KILAMBI, BHAKIARAJ DURAIRAJ PETER, NARAYANAN SUKUNATH, PARAMESWARAN VENKATESAN, THARA SATHYA NARAYANA, RAJAGOPAL SRIRAM, SAXENA SANJEEV, SHARMA GANAPAVARAPU VEERA RAGHAVA, SURENDRAN NARAYANAN, SAPPANIMUTHU THIRUNAVUKKARASU, TADIPARTHI RAVIKUMAR, SRINIVAS VISWESWARA AKELLA SATYA SURYA
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Pyrimidine compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof, are useful are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases and in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever.