15,16-METHYLENE-17-HYDROXY-19-NOR-21-CARBOXYLIC ACID Y-LACTONE DERIVATIVE,USE THEREOF,AND MEDICAMENT CONTAINING SAID DERIVATIVE

15,16-METHYLENE-17-HYDROXY-19-NOR-21-CARBOXYLIC ACID Y-LACTONE DERIVATIVE,USE THEREOF,AND MEDICAMENT CONTAINING SAID DERIVATIVE

The invention relates to 15,16-methylene-17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the general chemical formula I, and R4, R6a, R6b, R7 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the...

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Bibliographische Detailangaben
Hauptverfasser: MENGES FREDERIK, KUHNKE JOACHIM, RING SVEN, FRENZEL THOMAS, PRELLE KATJA, BOHLMANN ROLF, KLAR ULRICH, MUHN HANS-PETER, BORDEN STEFFEN, HUBNER JAN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates to 15,16-methylene-17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the general chemical formula I, and R4, R6a, R6b, R7 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.