CROSS-SPECIES-SPECIFIC BISPECIFIC BINDERS

The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KLINGER MATTHIAS, RAUM TOBIAS, STEIGER CAROLA, BLUMEL CLAUDIA, HAUSMANN SUSANNE, MEIER PETRA, MAYER PETRA, EBERT EVELYN, RIETHMULLER GERT, CIERPKA RONNY, MANGOLD SUSANNE, RAU DORIS, KISCHEL ROMAN, BURGHART ELKE, LUTTERBUSE RALF, STRASSER SUSANNE, SRISKANDARAJAH MIRNAALINI, HOFFMANN PATRICK, KUFER PETER, WISSING SANDRA, SCHALLER EVELYNE, KVESIC MAJK
Format:	Patent
Sprache:	eng
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Beschreibung
Zusammenfassung:	The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.