Aryl sulfamide derivatives and methods of their use

Aryl sulfamide derivatives and methods of their use

The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of cond...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MC COMAS, CASEY CAMERON, CRAWLEY, MATTHEW L, ZHANG, PUWEN, MAHANEY, PAIGE ERIN, VU, AN THIEN, COHN, STEPHEN TODD, KIM, CALLAIN YOUNGHEE, MANN, CHARLES WILLIAM, FENSOME, ANDREW, WOODWORTH JR, RICHARD PAGE, TRYBULSKI, EUGENE JOHN, GOLDBERG, JOEL ADAM, MARELLA, MICHAEL ANTHONY, SABATUCCI, JOSEPH P, TEREFENKO, EUGENE ANTHONY, JENKINS, DOUGLAS JOHN, O'NEILL, DAVID JOHN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention is directed to aryl sulfamide derivatives of formula I: or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.