Process for the preparation of abacavir

Process for the preparation of abacavir

Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R = H or a (C 1 -C 4 )-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The proce...

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Bibliographische Detailangaben
Hauptverfasser: BERENGUER MAIMO, RAMON, ELIAS RIUS, LAIA, MEDRANO RUPEREZ, JORGE, CAMPON PARDO, JULIO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R = H or a (C 1 -C 4 )-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.