A process for the purification of ropinirole hydrochloride

A process for the purification of ropinirole hydrochloride

An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water...

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Bibliographische Detailangaben
Hauptverfasser: ACHARYA, HITARTH HARSHENDU, LUTHRA, PARVEN KUMAR, SHANISHCHARA, ASHOK PRATAPRAI, DESHPANDE, PANDURANG BALWANT, SHAH, TRUSHAR RAJANIKANT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.