Thiazole compounds as protein kinase B (PKB) Inhibitors

The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.

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Hauptverfasser: WOHLHIETER, GEORGE E, WANG, XIANGHONG, HUANG, XIN, RIDER, JAMES T, LIU, QINGYIAN, VISWANADHAN, VELLARKAD N, LI, AIWEN, LEE, MATTHEW R, FOTSCH, CHRISTOPHER H, YUAN, CHESTER CHENGUANG, ZENG, QINGPING, HAH, NIANHE, WEILER, KURT E, YAO, GUOMIN, BOURBEAU, MATTHEW P, DOMINGUEZ, CELIA, TASKER, ANDREW S, ALLEN, JOHN G, TADESSE, SEIFU, HONG, FANG-TSAO
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creator WOHLHIETER, GEORGE E
WANG, XIANGHONG
HUANG, XIN
RIDER, JAMES T
LIU, QINGYIAN
VISWANADHAN, VELLARKAD N
LI, AIWEN
LEE, MATTHEW R
FOTSCH, CHRISTOPHER H
YUAN, CHESTER CHENGUANG
ZENG, QINGPING
HAH, NIANHE
WEILER, KURT E
YAO, GUOMIN
BOURBEAU, MATTHEW P
DOMINGUEZ, CELIA
TASKER, ANDREW S
ALLEN, JOHN G
TADESSE, SEIFU
HONG, FANG-TSAO
description The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Thiazole compounds as protein kinase B (PKB) Inhibitors
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