Thiazolyl-dihydro indazoles

Tricyclic thiazole derivatives (I) are new. Tricyclic thiazole derivatives of formula (I) and their salts, isomers, hydrates and solvates are new: A : aromatic ring; Y, Z : C, N, S; j : 1-3; k : 0 or 1; R a>H, COR 8>, NR 9>R 10>, NO 2, OR 8>, SR 11>, SOR 11>, SO 2R 11>, amino(1-6C)alkylcarbonylamino, or optionally substituted 1-6C (halo)alkyl, 2-6C alkenyl, 3-8C cycloalkyl, 3-8C cycloalkenyl, (hetero)aryl, 7-11C aralkyl, Spiro, Het or aryloxymethyl; R 8>1-6C alkyl, 3-6C cycloalkyl, NH 2 or (hetero)aryl, optionally substituted with halo or 1-4C alkyl; R 9>H, COOR 12>, CONR 12> or 1-6C alkyl, optionally substituted with COOH, di(1-6C alkyl)amino or Het, optionally substituted with 1-6C alkyl; or Het optionally substituted with 1-4C alkyl; R 10>H, 1-6C alkyl, 1-6C alkylcarbonyl or 2-6C alkynyl; R 11>1-6C alkyl optionally substituted with di(1-4C alkyl)amino; R b>R 4>, OR 4>, CH 2OR 4>, COR 4>, COOR 4>, CONR 4>R 5>, NR 4>R 5>, NR 5>COR 4>, NR 5>COOR 4>, NR 5>CONR 4>R 5>, NR 5>SOR 4> or NR 5>SO 2R 4>; R 4>, R 5>H, 1-6C (halo)alkyl, 1-6C hydroxyalkyl, 2-6C alkenyl, 2-6C alkynyl, 7-11C aralkyl, (2-4C alkenyl)(hetero)aryl, (2-4C alkynyl)(hetero)aryl, optionally substituted with tri(1-4C alkyl)silyl; or (hetero)aryl or Het optionally substituted with 1-4C alkyl; or R 4>+R 5>5-7-membered ring comprising C and optionally an O, N or S; R c>NHR 6> or NH-CO-B-R 7>; B : bond, 1-6C alkyl, 2-6C alkenyl or 2-6C alkynyl; R 6>H or 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 3-6C cycloalkyl, 3-6C cycloalkenyl, Het or (hetero)aryl optionally substituted with R 61>; R 61>halo, CF 3, OH, CN, OMe, 1-4C alkylsulfonyl; R 7>H, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl, 3-6C cycloalkyl, NR 71>R 72>, OR 72>, SR 72>, heteroaryl, Het, optionally substituted with 1-4C alkynyl or CONH 2; R 71>H, 1-6C alkyl, (CH 2) 2-4R 711> or butoxycarbonyl; R 72>H, 1-6C alkyl, optionally substituted with OH; R 711>NR 7111>R 7112>, Het, 1-imidazolyl or 2-(N-ethylpyrrolidine); R 7111>, R 7112>H or 1-6C alkyl; and provided that R a> is not H or Me when Y is N, Z is N, j is 2, k is 0, R b> is H or R c> is NHCONHEt. Spiro, Het and R 12> are not defined. [Image] ACTIVITY : Antiinflammatory; Antiallergic; Dermatological; Antipsoriatic; Antiseborrheic; Ophthalmological; Antiulcer; Hepatotropic; Neuroprotective; Antirheumatic; Antiarthritic; Osteopathic; Nephrotropic. MECHANISM OF ACTION : PI3 kinase (PI3K) inhibitor. In a PI3Kgamma inhibition assay, 2-acetylamino-4,5-dihydro-8-phenyl-8H-pyrazolo[4,5-g]benzothiazole (Ib