Imidazole derivatives as tyrosine kinase inhibitors

Imidazole derivatives as tyrosine kinase inhibitors

Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X and X' have the meanings indicated in claim 1 , are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.

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Bibliographische Detailangaben
Hauptverfasser: HOLZEMANN, GUENTER, RAUTENBERG, WILFRIED, JONCZYK, ALFRED, SOLER RIERA, MARTA, MITJANS, FRANCESC, ROSELL-VIVES, ELISABET, SUTTER, ARNE, ADAN, JAUME, STAHLE, WOLFGANG, CRASSIER, HELENE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of the formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X and X' have the meanings indicated in claim 1 , are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.