6-Substituted 2,3,4,5-tetrahydro-1H-benzo[D]azepines as 5-HT2C receptor agonists

6-Substituted 2,3,4,5-tetrahydro-1H-benzo[D]azepines as 5-HT2C receptor agonists

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other subst...

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Hauptverfasser: SIEDEM, CHRISTOPHER STEPHEN, BRINER, KARIN, SINGH, AJAY, MARTINE-GRAU, MAIA ANGELES, ALLEN, JOHN GORDON, COHEN, MICHAEL PHILIP, RODRIGUEZ MICHAEL JOHN, REINHARD, MATTHEW ROBERT, TIDWELL, MICHAEL WADE, BOYD, STEVEN ARMEN, MAZANETZ, MICHAEL P, CONWAY, RICHARD GERARD, HELLMAN, SARAH LYNNE, LEE, WAIY-MAN, ROTHHAAR, ROGER RYAN, GALKA, CHRISTOPHER STANLEY, WILLIAMS, ANDREW CAERWYN, DEO, ARUNDHATI S, ZHANG, DEYI, VICTOR, FRANTZ
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT 2C receptor agonists for the treatment of 5-HT 2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R 6 is -S-L-R 15 and other substituents are as defined in the specification.