NEW DIBENZOAZULENE COMPOUNDS AS TUMOR NECROSIS FACTOR INHIBITORS

The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively s...

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Bibliographische Detailangaben
Hauptverfasser:	PESIC, DIJANA, MERCEP, MLADEN, HRVACIC, BOSKA, MESIC, MILAN, ZUPANOVIC, ZELJKO
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain. Ovaj se pronalazak odnosi na dibenzoazulenska jedinjenja prikazana formulom I, kao i na njihove farmaceutske preparate za inhibiranje faktora alfa tumorske nekroze (TNF-α) i interleukina-1 (IL-1) kod sisara, za sva oboljenja i stanja u kojima je preterana sekrecija ovih medijatora. Jedinjenja prema ovom pronalasku pokazuju takodje i analgetsko dejstvo pa mogu da budu upotrebljena za otklanjanje bola.[The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.