AMIDES OF CYCLOMETHYLEN-1,2-DICARBOXYLIC ACIDS AND PROCESSES FOR OBTAINING THEREOF

The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: m is 0 or 1 and n is an integer varying between 0 and 3, are endowed with ACE-inhibiting activity and are thus therapeutically useful as anti-hypertension agents. For their preparation cyclomethylene-1,2-bicarboxylic acid or a de...

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Hauptverfasser: TURBANTI L, CERBAI G, CISCUOLI M
Format: Patent
Sprache:eng
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Zusammenfassung:The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: m is 0 or 1 and n is an integer varying between 0 and 3, are endowed with ACE-inhibiting activity and are thus therapeutically useful as anti-hypertension agents. For their preparation cyclomethylene-1,2-bicarboxylic acid or a derivative thereof is condensed either with an amino derivative containing a protected hydroxamic group, or with an aminoester, and then in the former case the protecting group is removed, or in the latter case is reacted with either hydroxylamine or N-alkylhydroxylamine.