EPI-EPIBATIDINDERIVATI

EPI-EPIBATIDINDERIVATI - Jedinjenja opšte formule XVII gde je R je niži alkil, niži alkenil, niži alkinil, ili cikloaikil, aril, heteroaril, aril-niži alkil ili heteroaril-mži alkil gde pomenute grupe mogu biti supstituisane sa jednim ili više supstituenata odabranih iz grupe koju Cine niži alkil, niži alkenil, niži alkinil, niži cikloaikil, aril, hetroaril, aril-niži alkil, hetroaril-niži alkil, hidroksi, niži alkoksi fenoksi, halogeno, halogeno-niži alkil, amino-, mono- ili disupstituisan amino-amido i/ili sulВ­fonamide; i R' je R' je vodonik, niži alkil, niži alkenil, niži alkinil, niži cikloaikil, niži cikloalkenil, niži cikloalkinil, aril-niži alkil, aril, heteroaril, halogeno-niži alkil, hidroksi-niži alkil ili acil; i njihove farmaceutski prihvatljive, aidicione soli kisleina koja pokazuju jak analgeziski efekat.Jedinjenja forВ­mule XVII su, nova jedinjenja sem kada R je 6-hloro-3-piridil a R' je vodonik. The subject-matter of the invention are epi-epibatidine derivatives of general formula wherein R stands for a C1-4-alkyl, C2-4-alkenyl, C2-4-alkinyl, C3-7-cycloalkyl, aryl, heteroaryl, aryl-C1-4-alkyl or heteroaryl-C1-4-alkyl group, said groups optionally being substituted by 1 or more C1-4-alkyl, C2-4-alkenyl, C2-4-alkinyl, C3-7-cycloalkyl, aryl, heteroaryl, aryl-C1-4-alkyl, heteroaryl-C1-4-alkyl, hydroxy, C1-4-alkoxy, phenoxy, halogen, halogeno-C1-4-alkyl and/or amino, amido and/or sulfonamido substituent(s), optionally mono- or di-C1-4-alkyl-, -C2-4-alkenyl- and/or -C2-4-alkinyl substituted, and R' represents hydrogen or a C1-4-alkyl, C2-4-alkenyl, C2-4-alkinyl, C3-7-cycloalkyl, C3-7-cycloalkenyl, C3-7-cycloalkinyl, aryl-C1-4-alkyl, aryl, hetero-aryl, halogeno-C1-4-alkyl, hydroxy-C1-4-alkyl or, preferably C1-4-aliphatic; aromatic or heterocyclic, acyl group with the proviso that, if R' stands for hydrogen, R is different from 6-(chloro)-pyrid-3-yl as well as optically active forms and acid addition salts thereof. Further aspects of the invention are concerned with a process and intermediates for preparing these compounds as well as medicaments containing them and their use.