CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS

This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula (I) wherein R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl, R4 is -COOH or tetrazolyl, A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, processes for their preparation and their use as therapeutic agents. Ovaj pronalazak se odnosi na jedinjenja koja su obično antagonisti IP receptora i koja su predstavljena Formulom (I) gde su R1, R2 i R3 svaki nezavisno u svakom pojavljivanju aril ili heteroaril, R4 je -COOH ili tetrazolil, A, B, m, n i r su kao što je definisano u opisu; ili individualni izomeri, racemske ili neracemske smeše izomera, ili njihove farmaceutski prihvatljive soli ili sovlati. Pronalazak se dalje odnosi na farmaceutske smeše koje sadrže takva jedinjenja, postupke za njihovo dobijanje i njihovu primenu kao terapeutskih sredstava.[This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula (I) wherein R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl, R4 is -COOH or tetrazolyl, A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, processes for their preparation and their use as therapeutic agents.