ANTIPICORNAVIRAL COMPOUNDS, THEIR PREPARATION AND USE

Peptido and peptidomimetic compounds of formula (I) wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided. Peptido i peptidomimetička jedinjenja formule: u kojoj su varijabile formule kao što je definisano u opisu, na poboljšani način inhibiraju ili zaustavljaju biološku aktivnost pikornavirusne 3c proteaze. Ova jedinjenja, kao i farmaceutske smese koje ih sadrže, korisna su za lečenje pacijenata ili organizama koji su zaraženi sa jednim ili više pikornavirusa, kao što je RVP. Takodje su dati i intermedijari i sintetički postupci za dobijanje takvih jedinjenja.[Peptido and peptidomimetic compounds of formula (I) wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.