S-NITROSOTHIOLS AS AGENTS FOR THE TREATMENT OF CIRCULATORY

Novi S-nitrozotolni derivati penicilamina ili glutationa, koji odgovaraju opštoj formuli (I) naznačen time: što su A i B fenil grupe ili zajedno formiraju ostatak -CH2-Q-CH2- konstituišući šestočlani prsten u kome Q predstavlja atom kiseonika, sumpora ili grupu N-R3, u kojoj je R3 vodonik ili alkil grupa C1-C4; R1 je acil ostatak koji može biti alifatična acil grupa C1-C5 ili ostatak glutaminske kiseline vezan preko svog neaminokiselinskog karboksila; R2 je hidroksilna grupa ili glicinski ostatak vezan preko peptidne veze; uz uslov da ako je R1 alifatični acil ostatak, onda je R2 hidroksilna grupa i ako je R1 ostatak glutaminske kiseline, onda je R2 glicinski ostatak. Nova jedinjenja imaju vazodilataciono dejstvo i inhibiraju agregaciju krvnih pločica, što ih čini pogodnim za tretman disfunkcija cirkulatornog sistema, posebno na kardiovaskularnom nivou. Novel S-nitrosothiols derivatives of penicillamine or glutathione, which correspond to following general formula(I) in which: A and B are phenyl groups or together form the rest -CH2-Q-CH2- constituting a ring of six units in which Q represents an atom of oxygen, of sulfur, or a group N-R , in which R is hydrogen or an alkyl group C1-C4; R is an acyl rest, which may be an aliphatic acyl group C1-C5 or a rest of glutamic acid bound via its non amino acid carboxyl; R is a hydroxyl group or a glycine rest bound via a peptide bond; with the proviso that if R is an aliphatic acyl rest then R is a hydroxyl group, and if R is a rest of glutamic acid then R is a glycine rest. The novel compounds have vasodilating activity arid inhibit the aggregation of the platelets, which make them useful for the treatment of dysfunctions of the circulatory system, specially at cardiovascular level.