NOVI DERIVATI OKSADIAZOL-ALKIL-PURINA I POSTUPAK ZA NJIHOVO DOBIVANJE

Novi derivati oksadiazol-alkil-purina opšte formule I gde A označava C1-4alkilen; R1 predstavlja C1-6alkil, hidroksialkil, halogenalkil, karboksialkil, C5-6cikloalkil ili aminoalkil opšte formule -(CH2)nNR2R3 gde je n ceo broj 1-3; R2 i R3 svaki predstavlja vodonik ili C1-4 alkil ili zajedno sa atomom azota na koji su vezani grade 5- ili 6-sto člani prsten koji može da sadrži atom azota ili atom kiseonika ka heteroatom; ili R1 predstavlja fenil, hidroksifenil, karboksifenil, benzil ili-dimetok-sibenzil, i farmaceutski prihvatljive njihove adicione soli sa neorganskim bazama. Prijava sadrži još 1 nezavisan i 1 zavisan zahtev. The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.