POBOLJŠANI POSTUPAK ZA DOBIJANJE 5-KARBAMOIL-5H-DIBENZ(b;f) AZEPINA

POBOLJŠANI POSTUPAK ZA DOBIJANJE 5-KARBAMOIL-5H-DIBENZ(b;f) AZEPINA formule I, naznačen time, što se vrši hlorkarbonilovanje 5H-dibenz/b,f/azepina formule II sa trihlormetil-hlorformijatom na temperaturi 60-140В°C u apolar-nom rastvaraču i zatim aminoliza dobivenog 5-hlorkarbonil-5H-dibenz/b,f/-azep...

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Bibliographische Detailangaben
Hauptverfasser:	SZABO, Z, TIMAR, T, CZIAKY, Z, BARTHA, F, HORVATH NEE BRADACS, K, GALAMB, V, KORIK NEE BALOGH, P, FRANK, L
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Zusammenfassung:	POBOLJŠANI POSTUPAK ZA DOBIJANJE 5-KARBAMOIL-5H-DIBENZ(b;f) AZEPINA formule I, naznačen time, što se vrši hlorkarbonilovanje 5H-dibenz/b,f/azepina formule II sa trihlormetil-hlorformijatom na temperaturi 60-140В°C u apolar-nom rastvaraču i zatim aminoliza dobivenog 5-hlorkarbonil-5H-dibenz/b,f/-azepina formule III sa gasovitim amonijaka u istom sudu bez izolovanja i prečišćavanja jedinjenja formule III. Prijava sadrži još 6 zavisnih zahteva. The invention relates to a process for the preparation of 5-(carbamoyl)-5H-dibenz[b,f]azepine of the formula by chlorocarbonylation of 5H-dibenz[b,f]azepine of the formula and ammonolysis of the resulting 5-(chlorocarbonyl)- 5H-dibenz[b,f]azepine of the formula with gaseous ammonia, in which the chlorocarbonylation of the 5H-dibenz[b,f]azepine of the formula II is carried out using trichloromethyl chloroformate in an apolar aromatic solvent, and the ammonolysis is carried out in the same device without separation and purification of the 5-(chlorocarbonyl)-5H-dibenz[b,f]azepine of the formula III in the unchanged reaction medium.