BENZIMIDAZOLES USEFUL AS PROTEIN KINASE INHIBITORS

Disclosed are substituted benzimidazole compounds of formula (I) wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention are useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are pr...

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Bibliographische Detailangaben
Hauptverfasser: SNOW, ROGER JOHN, SARKO, CHRISTOPHER, WILSON, NOEL, LEE, JINBO, PULLEN, STEVEN, ROTH, GREGORY, CYWIN, CHARLES
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are substituted benzimidazole compounds of formula (I) wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention are useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds. Prikazana su supstituisana benzimidazolna jedinjenja formule (I), u kojoj su R1, R2, R3, R4 i Xa definisani u opisu. Jedinjenja prema pronalasku, korisna su za lečenje oboljenja i patoloških stanja koja obuhvataju, inflamaciju, imunološke poremećaje i alergijske poremećaje. Takođe su prikazani postupci za pripremanje tih jedinjenja i farmacetuske kompozicije koje sadrže ta jedinjenja.[Disclosed are substituted benzimidazole compounds of formula (I) wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention are useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.