NONPEPTIDE SUBSTITUTED BENZOTHIAZEPINES AS VASOPRESSIN ANTAGONISTS

The invention is directed to nonpeptide substituted benzodiazepines of Formula (I), wherein A, X, Z, Bp, W, n, R1 and R2 are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula (I) and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed. Pronalazak se odnosi na nepeptidne supstituisane benzodiazepine formule (I), gde A, X, Z, Bp, W, n, R1 i R2 su opisani u prijavi, koji su korisni kao antagonisti vazopresin receptora za lečenje stanja koja povećavaju vaskularnu rezistenciju i srčanu insuficijenciju. Takodje su otkrivene farmaceutske kompozicije koje obuhvataju jedinjenja formule (I) i postupci lečenja stanja kao što je hipertenzija, kongestivni zastoj srca, srčana insuficijencija, koronarni vazospazam, srčana ishemija, ciroza jetre, renalni vazospazam, renalni zastoj, cerebralni edem i ishemija, udar, tromboza ili zadržavanje vode.[The invention is directed to nonpeptide substituted benzodiazepines of Formula (I), wherein A, X, Z, Bp, W, n, R1 and R2 are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula (I) and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.