PROCESS FOR PREPARING ANTI-INFLAMMATORY STEROIDS THE ANDROSTANE SERIES

PROCESS FOR PREPARING ANTI-INFLAMMATORY STEROIDS THE ANDROSTANE SERIES

The novel compound according to Claim 1 has a high local anti-inflammatory action, but only relatively weak systemic actions it can therefore be used for the local treatment of inflammations with a minimum risk of undesired systemic side effects. It is prepared by esterification of the corresponding...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WOOLLETT E.A, BAIN B.M, ENGLISCH A.F, PHILLIPPS G.H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The novel compound according to Claim 1 has a high local anti-inflammatory action, but only relatively weak systemic actions it can therefore be used for the local treatment of inflammations with a minimum risk of undesired systemic side effects. It is prepared by esterification of the corresponding 17 beta -carboxylic acid or a functional derivative thereof, in particular with a chloromethyl chloride, bromide or iodide, or by acetylation of the corresponding chloromethyl 17 alpha -hydroxy-17 beta -carboxylate, or by replacement of iodine or bromine by chlorine, e.g. by means of a metal chloride, in a corresponding iodomethyl or bromomethyl ester.