SERTRALINE ORAL CONCENTRATE

The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The present invention also provides a use of this concentrate composition to prepare an aqueous solution of sertraline. In addition, the present invention provides a method of using this concentrate composition to treat or prevent a variety of diseases or conditions. Finally, the present invention provides the compound, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine methanesulfonate. Ovaj pronalazak obezbedjuje suštinski nevodeni, tečni preparat farmaceutskog koncentrata za oralno unošenje koji sadrži sertralin ili njegtovu farmaceutski prihvatljivu so i jedno ili više farmaceutski prihvatljivih rastvornih sredstava. Ovaj pronalazak takodje obezbedjuje korišćenje ovog preparata koncentrata za dobijanje vodenog rastvora sertralina. Dodatno, ovaj pronalazak obezbedjuje postupak korišćenja ovog preparata koncentrata za tretiranje ili prevenciju mnoštva obolenja ili stanja. Finalno, ovaj pronalazak obezbedjuje jedinjenje (1S-cis)-4-(3,4-dihlorofenil)-1,2,3,4-tetrahidro-N-metil-1-naftalenamin metansulfonata.[The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The present invention also provides a use of this concentrate composition to prepare an aqueous solution of sertraline. In addition, the present invention provides a method of using this concentrate composition to treat or prevent a variety of diseases or conditions. Finally, the present invention provides the compound, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine methanesulfonate.