SUBSTITUTED PYRROLES AS ANTIPROLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER

Disclosed are novel substituted pyrroles having formula (I). These compounds and thelr pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. A...

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Hauptverfasser:	KONG, NORMAN, LOVEY, ALLEN JOHN JR, FOTOUHI, NADER, LIU, EMILY AIJUN, MULLIN, JOHN GUILFOYLE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Disclosed are novel substituted pyrroles having formula (I). These compounds and thelr pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and their use for the treatment and/or control of cancer. Otkriveni su novi supstituisani piroli formule (I). Ova jedinjenja i njihove farmaceutski prihvatljive soli su pogodni za davanje pacijentima u obliku kontinualnog infuzionog rastvora i prikladni su u proizvodnji lekova za lečenje i/ili kontrolu ćelijskih proliferativnih poremećaja, naročito kancera. Takodje su otkrivene farmaceutske smeše koje sadrže gore data jedinjenja i njihova primena u proizvodnji lekova za lečenje i/ili kontrolu kancera.[Disclosed are novel substituted pyrroles having formula (I). These compounds and thelr pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion solution and are useful in the treatment and/or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing the foregoing compounds and their use for the treatment and/or control of cancer.